Searchable abstracts of presentations at key conferences in endocrinology

ea0081p267 | Adrenal and Cardiovascular Endocrinology | ECE2022

Screening for non-classic congenital adrenal hyperplasia revisited: proposal for a new serum 17-hydroxyprogesterone threshold for which a cosyntropin stimulation test is indicated

Nakhleh Afif , Saiegh Leonard , Supino-Rosin Lia , Gendelman Raya , Shehadeh Naim , Zloczower Moshe

Introduction: The 250 μg cosyntropin stimulation test (CST) is used to diagnose non-classic congenital adrenal hyperplasia (NCCAH). The current recommendation to perform CST is when follicular morning 17-hydroxyprogesterone (17OHP) is higher than 6 nmol/l, and CST is considered positive for NCCAH diagnosis when the 60-minutes post-CST 17OHP serum level is above 30 nmol/l. These cut offs are mainly derived from radioimmunoassay (RIA) data. Recently, a validated enzyme-link...